Single limb immobilization model for bone loss from unloading
نویسندگان
چکیده
منابع مشابه
Periostin expression contributes to cortical bone loss during unloading.
Periostin (a product of Postn gene) is a matricellular protein which is increased in periosteal osteoblasts and osteocytes upon mechanical stimulation. We previously reported that periostin-deficient mice (Postn(-/-)) have low bone mass and a diminished response to physical activity due to a lack of sclerostin (a product of Sost gene) inhibition by mechanical loading. Here we hypothesized that ...
متن کاملImmobilization hypercalcaemia with severe bone mineral loss and hypogonadism.
Moderate hypercalcaemia occurred in a 17-year-old male who was immobilized with abdominal and right hip sepsis for 9 months after a motor vehicle accident. The hypercalcaemia was due to bone resorption, with a urine hydroxyproline:creatinine ratio of 0.203 (normal less than 0.017) and a urine calcium loss of 22.9 mmol/24 hr, associated with impaired renal function. There was radiological eviden...
متن کاملParadoxical Response to Mechanical Unloading in Bone Loss, Microarchitecture, and Bone Turnover Markers
BACKGROUND Sclerostin, encoded by the SOST gene, has been implicated in the response to mechanical loading in bone. Some studies demonstrated that unloading leads to up-regulated SOST expression, which may induce bone loss. PURPOSE Most reported studies regarding the changes caused by mechanical unloading were only based on a single site. Considering that the longitudinal bone growth leads to...
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We describe a new, simple immobilization protocol designed to induce muscle atrophy in lower hindlimb muscles in mice. Hindlimbs of C57BL6 mice were unilaterally immobilized for 7 days. Morphological analysis revealed that immobilization resulted in a significant reduction in muscle fiber size in both the extensor digitorum longus (EDL) and tibialis anterior (TA). By contrast, no significant ch...
متن کاملStrength training the free limb attenuates strength loss during unilateral immobilization.
The objective was to determine if strength training the free limb during a 3-wk period of unilateral immobilization attenuates strength loss in the immobilized limb through cross-education. Thirty right-handed participants were assigned to three groups. One group (n = 10) wore a cast and trained the free arm (Cast-Train). A second group (n = 10) wore a cast and did not train (Cast). A third gro...
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ژورنال
عنوان ژورنال: Journal of Biomechanics
سال: 2019
ISSN: 0021-9290
DOI: 10.1016/j.jbiomech.2018.11.049